Journal: Military Medical Research

Article Title: USP18 exacerbates myocardial I/R injury by inhibiting Parkin mitophagy through the deubiquitinase PTEN-L

doi: 10.1016/j.mmr.2026.100004

Figure Lengend Snippet: USP18 aggravates cardiac I/R injury through regulation of mitochondria and inhibition of mitophagy. a Electron microscopy image showing mitophagy in USP18-cKO mouse hearts ( n= 5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. b Protein levels of PINK1, Parkin, ubiquitinated proteins (Ub), P62, and LC3II in mitochondria from heart tissue in USP18-cKO and WT mice 24 h after I/R injury ( n =4). c Electron microscopy image showing mitophagy in USP18-overexpres (OV) mouse hearts ( n =5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. d Protein levels of PINK1, Parkin, Ub, P62, and LC3II proteins in mitochondria from the heart tissue of USP18-OV mice 24 h after I/R injury ( n =4). Color shift in mitophagy dye (red) and lysosomal dye (green) in NRVMs showing mitophagy in NRVMs with USP18 siRNA transfection ( e ) or Ad-USP18 infection ( f ) and the quantitative mitophagy index in each group ( n= 5). Scale bar=9 μm. Protein levels of PINK1, Parkin, Ub, P62, and LC3II in mitochondria from NRVMs transfected with USP18 siRNA ( g ) or infected with Ad-USP18 ( h ). ⁎⁎ P <0.01, ⁎⁎⁎ P <0.001 ⁎⁎⁎⁎ P <0.0001. USP18. Ubiquitin-specific protease 18; I/R. Ischemia/reperfusion; WT. Wild-type; KO. Knockout; P62. Sequestosome 1; LC3. Microtubule-associated protein 1 light chain 3; VDAC. Voltage-dependent anion channel.

Article Snippet: To block mitophagy, the selective dynamin-related protein 1 (Drp1) inhibitor Mdivi-1 was used (50 μmol/L, MedChemExpress, USA).

Techniques: Inhibition, Electron Microscopy, Transfection, Infection, Ubiquitin Proteomics, Knock-Out

Journal: Journal of Vascular Surgery: Venous and Lymphatic Disorders

Article Title: The American Venous Forum clinical practice guideline on the care of patients with upper extremity deep venous thrombosis

doi: 10.1016/j.jvsv.2026.102461

Figure Lengend Snippet: Upper extremity venous anatomy relevant to upper extremity deep venous thrombosis (UEDVT). Illustration of the major deep and superficial veins of the upper extremity, including the brachial, axillary, subclavian, internal jugular, and innominate veins, which together define the anatomic distribution of upper extremity deep venous thrombosis (UEDVT).

Article Snippet: Kuang et al, 2021 , Single-center retrospective cohort study. ICU inpatients with CVC-related UEDVT. , 2114 (209 symptomatic CA-UEDVTs) , Trauma , 2.05 , 1.33-3.16 , .001.

Techniques:

Journal: Journal of Vascular Surgery: Venous and Lymphatic Disorders

Article Title: The American Venous Forum clinical practice guideline on the care of patients with upper extremity deep venous thrombosis

doi: 10.1016/j.jvsv.2026.102461

Figure Lengend Snippet: Costoclavicular compression in venous thoracic outlet syndrome (vTOS). Schematic depiction of subclavian vein compression within the costoclavicular space between the clavicle, first rib, subclavius muscle, and costoclavicular ligament, illustrating the pathophysiological mechanism underlying vTOS-associated upper extremity deep venous thrombosis (Paget-Schroetter syndrome).

Article Snippet: Kuang et al, 2021 , Single-center retrospective cohort study. ICU inpatients with CVC-related UEDVT. , 2114 (209 symptomatic CA-UEDVTs) , Trauma , 2.05 , 1.33-3.16 , .001.

Techniques:

Journal: Journal of Vascular Surgery: Venous and Lymphatic Disorders

Article Title: The American Venous Forum clinical practice guideline on the care of patients with upper extremity deep venous thrombosis

doi: 10.1016/j.jvsv.2026.102461

Figure Lengend Snippet: Catheter-associated upper extremity deep venous thrombosis (UEDVT). Illustration of a peripherally inserted central catheter ( PICC ) within a large upper extremity vein with associated thrombus formation, demonstrating a common mechanism of secondary catheter-associated upper extremity deep venous thrombosis (UEDVT).

Article Snippet: Kuang et al, 2021 , Single-center retrospective cohort study. ICU inpatients with CVC-related UEDVT. , 2114 (209 symptomatic CA-UEDVTs) , Trauma , 2.05 , 1.33-3.16 , .001.

Techniques:

Journal: International Journal of Genomics

Article Title: Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer

doi: 10.1155/ijog/1884334

Figure Lengend Snippet: Identification of differential exosome‐related genes. (A) Venn diagram of 34 OCGs. (B) Forest plot of univariate regression analysis. (C–F) Kaplan–Meier′s analysis was used to compare the OS of patients in the four genes ( TRAF2 , NOX4 , ASCL2 , and MMRN1 ) of the high‐expression and low‐expression groups. (G–J) Kaplan‐Meier′s analysis was used to compare the disease‐free interval (DFI) events of patients in the four genes of the high‐expression and low‐expression groups.

Article Snippet: Exosome‐related DEGs were defined as being significantly up‐ or downregulated when p values were < 0.05 and absolute log2 fold change (LFC) > 1.

Techniques: Expressing

Journal: International Journal of Genomics

Article Title: Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer

doi: 10.1155/ijog/1884334

Figure Lengend Snippet: Identification of heterogeneous GC cell subpopulations. (A) First Umap cell subgroups. (B, C) Enrichment for the risk scores varies in different cell subsets. (D) The log2FC scores in different cell subsets. (E) The expression of four DEGs in different cell subsets.

Article Snippet: Exosome‐related DEGs were defined as being significantly up‐ or downregulated when p values were < 0.05 and absolute log2 fold change (LFC) > 1.

Techniques: Expressing

Journal: International Journal of Genomics

Article Title: Exosome‐Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer

doi: 10.1155/ijog/1884334

Figure Lengend Snippet: The association between the ERGRS and immune infiltration in the TME. (A) Heat map depicting various immune cells in the high‐ and low‐risk subgroups. (B) Bubble plot of the expression of these four DEGs and immune cells. (C) Differential analysis of the relative infiltration content of 28 types of immune cells between the high‐ and low‐risk subgroups. (D) Difference in the expression of immune checkpoints between the high‐ and low‐risk subgroups. (E) Kaplan–Meier′s curves for patients with high‐risk and low‐risk scores in the IMvigor210 cohort. (F) The comparison of risk scores in groups with different immunotherapeutic treatment response statuses in the IMvigor210 cohort. (G) Treatment response rates of immunotherapy in the high‐ and low‐risk groups in the IMvigor210 cohort ( p = 0.005). NR represents SD/PD; R represents CR/PR. (H) ROC curves evaluate the predictive accuracy of the risk score in the IMvigor210 cohort. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001; NS, no significance.

Article Snippet: Exosome‐related DEGs were defined as being significantly up‐ or downregulated when p values were < 0.05 and absolute log2 fold change (LFC) > 1.

Techniques: Expressing, Comparison